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The comedian tackles serious topics with her sarcastic wit and crazy conclusions. The Midwesterner has scored her own specials on HBO, Showtime and Comedy Central. She’s also a late-night fave with such hosts as Jay Leno, Conan O'Brien and David Letterman. By taking her audiences on a trip through everyday life, from sports to the singles scene, Madigan has previously been named the American Comedy Awards’ Best Female Stand-Up Comedian.